Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing
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چکیده
منابع مشابه
The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription
Bud27, the yeast orthologue of human URI/RMP, is a member of the prefoldin-like family of ATP-independent molecular chaperones. It has recently been shown to mediate the assembly of the three RNA polymerases in an Rpb5-dependent manner. In this work, we present evidence of Bud27 modulating RNA pol II transcription elongation. We show that Bud27 associates with RNA pol II phosphorylated forms (C...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Analysis of URI Nuclear Interaction with RPB5 and Components of the R2TP/Prefoldin-Like Complex
Unconventional prefoldin RPB5 Interactor (URI) was identified as a transcriptional repressor that binds RNA polymerase II (pol II) through interaction with the RPB5/POLR2E subunit. Despite the fact that many other proteins involved in transcription regulation have been shown to interact with URI, its nuclear function still remains elusive. Previous mass spectrometry analyses reported that URI i...
متن کاملPrefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin
We describe the discovery of a heterohexameric chaperone protein, prefoldin, based on its ability to capture unfolded actin. Prefoldin binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. Deletion of the gene encoding a prefoldin subunit in S. cerevisiae results in a phenotype similar to those found when c-cpn is mutated, namely impaired functions of the actin...
متن کاملCoxsackievirus type A16 infection in a neonate.
Hamilton, J. R., Lynch, M. J., and Reilly, B. J. (1969). Active coeliac disease in childhood. Quarterly Journal of Medicine, 38, 135-137. Lascari, A. D. (1973). Differential diagnosis. In Leukemia in Childhood, pp. 111-140. Edited by A. D. Lascari. Thomas: Springfield. Walker-Smith, J. (1975). Coeliac disease. In Diseases of the Small Intestine in Childhood, pp. 52-88. Edited by J. Walker-Smith...
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ژورنال
عنوان ژورنال: Cell Reports Medicine
سال: 2020
ISSN: 2666-3791
DOI: 10.1016/j.xcrm.2020.100125